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Melanotan 1 (Afamelanotide) is a synthetic linear analogue of alpha-melanocyte-stimulating hormone (α-MSH) with a molecular weight of approximately 1,646.9 Da, incorporating a [Nle4, D-Phe7] substitution that confers resistance to enzymatic degradation and significantly extends plasma half-life compared to the native 13-amino acid α-MSH sequence — while retaining high selectivity for the MC1R melanocortin receptor subtype expressed on melanocytes