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These include chronic stress, poor diet, inadequate sleep, smoking, excessive alcohol consumption, pollution exposure, UV radiation, aging, and intense physical stress

Neurological function

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The observed capability of Nle 1 -AngIV and dihexa to induce spinogenesis and synaptogenesis in these same cultures offers additional support for the notion that both act by shifting HGF’s dose-response curve to the left and render biologically subthreshold levels of HGF physiologically meaningful