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BV2 cells exhibit an intrinsically activated phenotype and respond robustly to inflammatory stimuli such as LPS, show enhanced phagocytosis, increased production of reactive oxygen and nitrogen species (ROS and RNS, respectively), and induction of pro-inflammatory gene programs following exposure to Aβ or α-Syn

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Multiple mechanisms of action can be associated with the neuroprotective effects of DHA and include antioxidant properties and activation of distinct cell signaling pathways