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In agreement, the blanket use of NRF2 inducers or inhibitors along with anticancer therapies cause adverse effects in some preclinical cancer models
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The findings are specific, and one of them is very commonly reported backwards: BPC-157 did not directly increase fibroblast proliferation — MTT assay showed no direct effect It did significantly increase cell survival under hydrogen peroxide oxidative stress It increased fibroblast migration in a dose-dependent manner It induced F-actin formation and dose-dependently increased phosphorylation of FAK and paxillin — proteins central to the cell migration pathway [2] The distinction matters
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