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During ischemia, AKI is exacerbated by elevated levels of free iron in the kidney, downregulation of GPX4 and SLC7A11, and depletion of blood GSH, leading to the activation of ferroptosis and subsequent tubular necrosis (Zhao et al., 2020 demonstrated that iron deficiency worsened rhabdomyolysis (RM)-induced AKI
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Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro
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