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→ Hormonal Suppression → Suppresses natural testosterone , even at moderate doses (20–50 mg/day) → Rapid decline in LH and FSH , especially after 4–6 weeks → Post-cycle therapy (PCT) is required to restore HPTA function → Liver Toxicity → Anavar is a C-17 alpha alkylated oral steroid , making it hepatotoxic → Elevated liver enzyme levels are common → Risks increase with cycle duration or stacking with other orals → Lipid and Cardiovascular Impact → Decreases HDL (good cholesterol) → Increases LDL (bad cholesterol) → May negatively affect blood pressure and cardiovascular strain → Other Possible Side Effects → Acne and oily skin (especially in androgen-sensitive individuals) → Hair thinning in genetically predisposed users → Appetite suppression → Reduced libido and potential sexual dysfunction post-cycle “Oxandrolone impairs lipid balance and suppresses testosterone, requiring post-cycle therapy and monitoring of hepatic biomarkers.” — Basaria et al., Journal of Andrology MK-677: Non-Suppressive, Non-Toxic, but Metabolically Active MK-677 is not a steroid or a SARM , and does not suppress testosterone or strain liver enzymes