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While this isn’t medical advice, the research gaps outlined above point toward a few groups for whom the uncertainty is especially significant: Anyone who is pregnant or breastfeeding Anyone with a personal or family history of cancer, given unresolved questions around angiogenesis-related compounds and cell growth Anyone with significant cardiovascular or liver conditions Anyone currently taking medications with narrow safety margins, given unknown interaction risks Because of the regulatory status and evidence gaps discussed throughout this piece, decisions about experimental peptides belong in a conversation with a qualified healthcare provider — not a blog post, and not a forum thread

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CRH is a potent stimulator of TSH release from the pituitary of amphibians, fish and birds [reviewed by De Groef (216)]