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Apremilast ameliorates methotrexate-induced renal injury in rats: role of TLR4/NF-κB/P38 MAPK/caspase-3 and Nrf2/HO-1 signaling pathways | Naunyn-Schmiedeberg's Archives of Pharmacology | Springer Nature Link
The excellent side effect profile of these agents would also suggest that they may complement interventions which have displayed potential benefits in treating Covid-19, such as Remdesivir (132) and convalescent plasma (133, 134), which we believe warrants their experimental use in clinical trials
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