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PE-22-28 PE-22-28 is a synthetic peptide that activates TrkB receptors and modulates TREK-1 potassium channels
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In this reaction, methylene-THF is converted to dihydrofolate (DHF) and then reduced back to THF with the help of dihydrofolate reductase (DHFR) via the folate cycle (Figure 2) [54]
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