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The NIH/PMC systematic review on BPC-157 in orthopaedic sports medicine found that preclinical studies indicate its potential for promoting healing in musculoskeletal injuries including fractures, tendon ruptures and ligament tears, and noted that in one retrospective observation involving intraarticular injection for chronic knee pain, 7 of 12 patients reported relief for more than 6 months

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Representative mutations are those that interfere with contact points between the α and β subunits (e.g., Hb Philly [β 35Tyr→Phe ]), alter the helical segments (e.g., Hb Genova [β 28Leu→Pro ]), or disrupt interactions of the hydrophobic pockets of the globin subunits with heme (e.g., Hb Köln [β 98Val→Met ]) (Table 127-3)