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Because apoptosis and autophagy interact in auditory hair cells after cisplatin administration, U0126, a specific inhibitor of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) signaling pathway, has neuroprotective effects, and its pre-treatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells (Wang et al., 2021)
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