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A 2003 study by Staresinic, Sebecic, Patrlj, and colleagues in Journal of Orthopaedic Research used a rat Achilles tendon transection model with BPC-157 administered intraperitoneally once daily at 10 µg/kg, 10 ng/kg, or 10 pg/kg and reported improved load-to-failure, Young's modulus of elasticity, and Achilles functional index scores, reduced tendon defect size by day 14, and increased tendocyte outgrowth in vitro — with specific numerical effect sizes and p-values not reported in the abstract

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This synthetic 11-amino-acid peptide, also known as cibinetide, has completed multiple human clinical trials specifically targeting neuropathy, with results that have attracted FDA Fast Track designation and orphan drug status

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