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This eicosanoids class switching, characterized by an increased biosynthesis of SPMs and a decrease of eicosanoids involved in the initiation of inflammation, results from the coordinated action of enzymes such as the different isoforms of lipoxygenases (15LO, 5LO, and 12LO), of COX (COX1 and COX2), as well as the leukotriene A4 hydrolase (LT4H) ( Figure 3 )

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Genetic variations in enzymes involved in one carbon metabolism, such as the MTHFR gene, can also reduce methylation efficiency