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studies used the Immediate Post-Concussion Assessment, Cognitive Testing, Rivermead Post-Concussion Questionnaire, and PTSD Checklist–Military (PCL-M) as the primary and secondary endpoint measures
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systemic enhancement could have unpredictable immunological consequences Cell-penetrating peptide concerns: The Tat CPP sequence enables non-selective cellular uptake, meaning all cell types are affected -- there is no tissue selectivity Comparative Safety# Tat-Beclin-1's approach of enhancing an existing cellular process is generally considered more physiological than FOXO4-DRI's induction of cell death
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