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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Dudley M.A., Wang H., Hachey D.L., Shulman R.J., Perkinson J.S., Rosenberger J., Mersmann H.J
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By exploiting tumor-associated features, such as overexpressed enzymes, hypoxia, reactive oxygen species, or cell surface antigens, prodrugs enable the conditional activation of potent yet systemically toxic molecules in target tissues
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