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10.1016/j.molcel.2012.09.025 [DOI] [PMC free article] [PubMed] [Google Scholar] Seo M
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Pro-inflammatory adipokines (e.g., leptin, resistin) and adipose-derived exosomes (carrying miRNAs like miR-3074-5p) create a chronic inflammatory joint microenvironment by polarizing synovial macrophages toward an M1 phenotype and inhibiting anti-inflammatory adiponectin (16–18)
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