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In studies of atherosclerosis, ATOX1 is increased in the intima of atherosclerotic lesions in ApoE −/− mice and localizes to the nucleus in pathologic conditions such as hypertensive and atherosclerotic vessels [122]
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Activated RIP3 phosphorylates MLKL101, and the phosphorylated MLKL translocates to the cell membrane where MLKL interferes with membrane integrity, causing necrotic cell death99
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