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Fibroids are benign monoclonal tumors arising from the smooth muscle cells of the myometrium and contain a large amount of extracellular matrix (ECM) such as collagen, proteoglycan, fibronectin, and are surrounded by a thin pseudocapsule of areolar tissue and compressed muscle fibers [39]
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Notably, KCNIP4 rs12501548, KLHL8 chr4:88356546, rs349715 (intergenic), and NOTCH2 rs4659248 all demonstrated a detrimental effect on MASLD fibrosis stage in postmenopausal but not premenopausal women
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