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LPS induces active HMGB1 release from hepatocytes into exosomes through the coordinated activities of TLR4 and caspase-11/GSDMD signaling

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Animal manipulations were carried out according to the National and European Community guidelines for animal care (DL 116/92, of application of the European Communities Council Directive 86/609/EEC) and of ethical guidelines of the University of Florence, consistent with the Guide for the Care and Use of Laboratory Animals of the US National Institutes of Health (NIH Publication No