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(2007) demonstrated that dipeptides constitute a noticeable fraction of urinary amino acids in Pept2-deficient animals, and dipeptide-bound glycine and cystine are increased in their urine samples, suggesting that Pept2 is critical for the reabsorption of Cys-Gly originating from GSH breakdown, and that it contributes to reabsorptions of amino acids that may be used for GSH resynthesis

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To verify the inhibitory effects of NBDHEX on lactic acid signaling, we found that NBDHEX maintained the interaction of the tri-complex (Fig