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IBB associates primarily with the C-terminal region III (HEATs 7–19), whereas Ran-GTP binds to the N-terminal arch comprising HEATs 1–13, validating previous mutagenesis studies 16 , with some overlap in HEAT 13

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The inflammatory effects of PM 10 have been demonstrated in experimental animal studies by using direct instillation into the lung prior to human studies that showed pulmonary effects after experimental exposure to PM 17