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Unfavorable microenvironment Immunosuppressive environment The unfavorable microenvironment is another significant contributor to T cell exhaustion and includes high levels of immunosuppressive cytokines, harmful metabolites, nutrient deficiency, and low oxygen levels, creating an immunosuppressive environment
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↑ "Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo"
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