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a "derivative of an (native or non-native) amino acid sequence according to SEQ ID NOs: 1 -4, 1 3-20 and 33-1 00" is preferably an amino acid sequence derived from any of the sequences according to SEQ ID NOs: 1 -4, 1 3- 20 and 33-1 00, wherein the derivative comprises at least one modified L- or D-amino acid (forming non-natural amino acid(s)), preferably 1 to 20, more preferably 1 to 10, and even more preferably 1 to 5 modified L- or D-amino acids

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In this study, rats were fed with a calorie-restrictive KD or a standard diet for four weeks

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