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This is largely due to the difficulty in controlling confounding variables such as age, sex, psychiatric comorbidities, and the concomitant use of other medications, which limits the reproducibility and generalizability of findings ( As SSRIs represent the primary class of antidepressants currently in use, the main biological markers studied to date are components of the serotonergic neurotransmission system, including synthetic enzymes, transporters, receptors, and metabolic enzymes for this neurotransmitter (Veenstra-VanderWeele et al., 2000)

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