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Increased activation of MMPs is linked to epithelial barrier leakiness, as observed in UC patients, where higher levels of MMP-9 and -2 were associated with lower lactulose to mannitol ratio in urine, an indicator of higher barrier permeability [100] (Fig
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It has been shown that rhein inhibits CYP2C9, CYP1A2, CYP2E1, CYP2D6 and CYP3A enzymes in rat liver (Tang et al., 2009)
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