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For instance, AAV9-mediated delivery of the very longchain acylCoA dehydrogenase (VLCAD) gene was used to treat very long-chain acyl-CoA dehydrogenase deficiency, directly correcting the β-oxidation defect and maintaining stable cardiac function for up to 6 months in mice ( 5.3.2 Stem cell therapy Stem cells possess the remarkable ability to self-renew and undergo multilineage differentiation, enabling them to develop into various cell types such as cardiomyocytes and vascular endothelial cells
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