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Why preclinical evidence has limitations Preclinical research cannot independently determine: Safe human exposure Effective clinical dosing Appropriate administration routes Long-term risks Drug interactions Reproductive effects Immunogenicity Clinical effectiveness These require appropriately controlled human research
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Chatterjee et al., 2000) Similarly, the GSH concentration in astrocytes does not appear to be affected by ONOO - exposure (Bolanos et al., 1995)
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