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showed that Srx is specific for deglutathionylating Prx I (known to have a high affinity to Srx) and that the level of S-glutathionylated Prx I was substantially elevated in Srx-knockdown cells [109]

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It is possible that the optimal synergistic dosages of these vitamins have not yet been identified or that compounds produced during the metabolism of homocysteine may increase inflammation and override the beneficial effects of supplementation.26 Diabetes Elevated plasma homocysteine has been associated with an increased risk of insulin resistance and type 2 diabetes