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CagriSema: a novel dual-pathway approach to target obesity and its complications
This randomized controlled trial found that intramuscular cobalamin injection produced dramatically higher peak blood concentrations (Cmax ≈38.5 nmol/L) than intranasal administration (≈1.0 nmol/L) in elderly patients, consistent with injection bypassing the gut’s limited absorption pathway entirely
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This is likely also the case during systemic viral infections that result in severe oxidative stress (cell/tissue necrosis), a usual indication of late and failed attempts by the host to induce resistance (Hernández et al., 2016
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