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The novel PVP-modified copper/hafnium-doped phosphate nanostimulator (CHP) enables cuproptosis-synergized radiosensitization under low-dose X-ray radiation and activates immunogenic cell death (ICD) to enhance anti-tumor immunity by depleting GSH, alleviating hypoxia, and reprogramming the tumor microenvironment ( Many traditional Chinese medicines have shown great potential in the combined treatment of tumors
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