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Bocci repeatedly published on OT effect on modulating inflammatory cytokines and interferons, summarizing effects in his book.⁸ One remarkable Cuban report in rodents demonstrated that ozone preconditioning given by intraperitoneal injection was about as effective in reducing TNF-α induction by injection of LPS as the powerful steroid dexamethasone.⁹ “NF-κB has long been considered the holy grail as a target for new anti-inflammatory drugs

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Despite significant research, the question still remains, “Why do melanocytes begin to disappear?” However, there are a few theories