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Such proteins can be modified in various ways, and reactivity is greatly enhanced for Cys whose thiol side chain is in the thiolate form, i.e., deprotonated at physiological pH (S − ): sulfenylation, nitrosylation, glutathionylation, persulfidation, and disulfide formation, responding to different oxidants (FIGURE 1)
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(141) in conjunction with chemotherapeutic drugs can reduce the resistance of tumor tissues
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