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Additionally, ectopic endometrial tissues in EMs patients exhibit higher levels of necroptosis mediators, including RIPK3 and MLKL, compared with normal tissues, providing indirect support for necroptosis’s involvement in EMs (Huang et al., 2022), tanshinone ( 5 Clinical translation: therapeutic strategies and synergistic potential of natural products Although extensive preclinical studies have demonstrated the potential of natural products such as curcumin and resveratrol to treat EMs by regulating PCD, validation of their clinical efficacy remains crucial for translation into practice
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