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Use of "Phasic” axons that fatigue in their glutamate neurotransmitter release have lower glutamate levels than “tonic” glutamate axons with greater glutamate levels (34)

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Successful clinical translation, however, requires a nuanced understanding of the context-dependent actions of BAs, specific BA species, receptor expression, signaling bias, and the intricate BA-microbiota-immune axis within the disease microenvironment, paving the way for novel immunotherapeutic interventions