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GSH-Cys adducts may be reduced by glutaredoxins (Grxs), which are homologs to Trxs (Martin, 1995), and share similar binding modes of the protein substrate with Trxs
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doi: 10.1126/scitranslmed.aav0936 Summary Keywords colorectal cancer, drug tolerance, ferroptosis, glutathione peroxidase 4 (GPX4), ferrous iron Citation Zhang X, Ma Y, Ma J, Yang L, Song Q, Wang H and Lv G (2022) Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells
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