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In rodent, the ability of opioid to promote analgesia to different type of stimuli could be measured using numerous behavioral paradigms including hot-plate test and tail-flick for thermal nociception (Barrot, 2004), doses (Huidobro et al., 1976) and even the pharmacological effect observed (Mohammed et al., 2013)
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37 5-Hydroxytryptamine is then metabolised into 5-hydroxyindoleacetic acid (5-HIAA) primarily by monoamine oxidase A (MAO-A)
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