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Although these results might add further insights on the kava involvement in liver injury as hepatic hypertrophy was registered, the mechanisms remain largely unknown and several hypotheses have been proposed as described below

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However, excessive or uncontrolled type-I IFN production can be detrimental, as seen in various so-called interferonopathies 47 , such as Aicardi–Goutières syndrome and STING-associated vasculopathy with onset in infancy, as well as secondary haemophagocytic lymphohistiocytosis (sHLH) 47,48,49,50,51,52