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In vivo and in vitro models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expression of genes related to glutathione anabolic metabolism (GCLC, GCLM, and SLC7A11) was significantly down-regulated
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NAC treatment enhanced the ex vivo expansion of single circulating tumor cells comprising a small set of metastatic precursors through mitigation of oxidative stress [22]
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