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Insulin-like growth factor-1 deficiency and metabolic syndrome | Journal of Translational Medicine | Springer Nature Link
In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)
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It plays a critical role in methylation, a biochemical process vital for DNA synthesis, detoxification, and neurotransmitter production[196]
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