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In the CNS, the presence of circulating proinflammatory cytokines promotes dysfunction in glutamate reuptake and a decrease in dopamine, both related to the development of fatigue and both capable of inducing an increase in oxidative stress through different pathways 57
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In a study where adult male C57/BL6 mice were orally administered 5 mg/kg/day MeHg for 28 days, Kirkpatrick and collaborators [119] observed that GR activity decreased in liver and increased in brain tissue of MeHg-treated animals
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