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However, the observation that caffeine reduces the stimulation in-vivo (AcbSh DA, by reverse dialysis) and in-vitro (pVTA DA neuronal firing) by exogenous salsolinol, as well as the stimulation of pVTA DA neuronal firing in-vitro by morphine, confirms that salsolinol generation-independent mechanisms should be envisioned

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Additionally, GRP 78 can bind to and inhibit the activity of the pro-apoptotic protein BIK on the endoplasmic reticulum, thereby promoting the expression of Bcl-2 and inhibiting cell apoptosis