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There is a particular need for human studies focused on the following: (i) validation of airway and systemic GSH/GSSG redox balance as a biomarker of asthma susceptibility, (ii) the natural history of GSH/GSSG redox balance in asthma across the lifespan, (iii) the specific role of GSH/GSSG redox balance in clinical manifestations of the disorder, including asthma severity and the response to secondary insults, (iv) the utility of GSH/GSSG redox balance as a predictor and indictor of asthma treatment responsiveness, and (v) therapeutic approaches to restore the GSH/GSSG redox balance in asthma and modify the course of the disorder

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The development of blood-brain barrier permeable AT 4 receptor agonists and antagonists presents a novel and promising new strategy for the treatment of several of these clinical dysfunctions (174–177)