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Stromal interaction molecule 1 (STIM1) detects ER calcium depletion, translocates to ER-plasma membrane junctions, and activates Ca 2+ release-activated channels (CRAC) by tethering Orai proteins, triggering CaMKKΞ² activation, which phosphorylates AMPK at Thr172
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10.1007/s00109-026-02641-5 [DOI] [PubMed] [Google Scholar] Wang J
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