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Another study demonstrated that TSA hindered HSC activation by inhibiting KRAS protein and modulating the PI3K/AKT and Nrf2/heme oxygenase-1 (HO-1) pathways, reducing collagen deposition and reversing the progression of CCl4-induced hepatic fibrosis in mice (63)
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doi: 10.3390/ijms232314710, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 313
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