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There are four different methods namely dose by factor, similar drug, pharmacokinetically guided, and comparative approaches are described in literature to assess the initial dose.[1] The dose by factor method is an empirical approach and use the no observed adverse effect levels (NOAEL) of drug from preclinical toxicological studies to estimate human equivalent dose (HED).[2] Here, the dose selection is based on minimum risk of toxicity, instead of choosing one with minimum pharmacologic activity in humans
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’H NMR (400 MHz, DMSO-de) 5 13.32 (s, 1H), 8.50 (s, 1H), 8.32 (s, 1H), 8.18 (d, J= 7.1 Hz, 1H), 7.97 (d, J = 11.1 Hz, 1H), 7.58 (s, 2H), 7.44 (d, J= 7.4 Hz, 1H), 7.10 (t,J= 54.1 Hz, 1H), 6.78 (d, J = 7.4 Hz, 1H), 5.22 - 5.11 (m, 1H), 5.11 - 4.87 (m, 1H), 4.45 - 4.28 (m, 1H), 4.26 - 4.11 (m, 1H), 2.22 - 1.96 (m, 2H), 1.36 (d, J = 6.0 Hz, 3H)
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