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Frontiers | Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

Over 90% of the body’s 5-HT is synthesized in the gut by enterochromaffin cells, which absorb tryptophan from dietary proteins as a substrate for 5-HT synthesis

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Influenced by hormones, immunomodulators and metabolic factors, these autoimmune diseases exhibit features of ferroptosis features, including iron metabolism disorder and lipid peroxide accumulation at different stages of development, suggesting that ferroptosis plays an important regulatory role in the onset and progress of autoimmune diseases