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In the correlation analysis, there were only four biomarkers: HR (r= - 0.9998, R 2 = 0.9997, p = 0.0113), TLR4 (r= - 0.9617, R 2 = 0.9248, p = 0.0383), EF% (r= - 0.9580, R 2 = 0.9178, p = 0.0420) and HW/BW (r= -0.9551, R 2 = 0.9122, p = 0.0449) that showed a significant negative correlation with HMGB1 when it is treated as the independent variable
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The formation of metal sulphides as detoxification forms of some thiol-binding metals has been long recognized in several organisms, from microorganisms and plants to mammals
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