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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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(2019) reviewed Cerebrolysin for vascular dementia and found that intravenous courses improved cognition and general function without a clear adverse-effect signal — but graded the evidence very low quality due to heterogeneity and high risk of bias, concluding that any benefits may be too small to be clinically meaningful and that the evidence base remains weak (PMID: 31710397) Neurotrophic Modulation: Rejdak et al