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Cycle Guidelines (community-derived from compound-level data) Approach Pre-blended daily Loading — Maintenance 0.5–2.0 mg total blend daily Total cycle 6–12 weeks Common context Convenience-first, steady exposure Approach Separate vials standard Loading Weeks 1–4 Maintenance Weeks 5–8 Total cycle 8–12 weeks Common context Loading-then-taper for injury planning Approach Separate vials extended Loading Weeks 1–4 Maintenance Weeks 5–12 Total cycle 12 weeks Common context Slower-healing tissue research planning These are research-planning structures, not treatment plans

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It has been proposed that cell-cycle arrest at G2 mediated by TOR inactivation and exposure to cAMP are both required to induce appressorium formation