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FIGURE 2 Alcohol intake in adulthood promotes oxidative stress and neurodegeneration particularly in the hippocampus, entorhinal cortex and olfactory bulb (47, 48)

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Nutrients needed to support Phase II detoxification include: Amino acids: phase II is highly reliant on amino acids such as cysteine, glutamic acid, glutamine, glycine, methionine, taurine Glutathione B-vitamins, in particular B6, B9 and B12 Sulphur Signs and symptoms of Liver Dysfunction & Detoxification The signs and symptoms of liver dysfunction are varied and may include the following: GIT symptoms: constipation, nausea, bloating, flatulence Intolerance to fat, alcohol and caffeine Fatigue and lethargy Headaches / migraines Allergies and chemical sensitivities PMS and other hormonal imbalances Blood sugar swings Halitosis and body odour Cloudy urine Visual disturbances Fluid retention Sinus congestion Skin disorders Coating on tongue / swollen tongue Investigations Liver Function Test (LFT): to rule out more serious conditions Functional Liver Detoxification Profile Advanced Stool Testing – source of toxins Intestinal Permeability SIBO Comprehensive blood chemistry panel TREATMENT STRATEGY FOR LIVER DYSFUNCTION & DETOXIFICATION Identify and correct endogenous sources of toxins such and bacterial infections, SIBO, intestinal permeability, mineral imbalances and deficiencies etc Reduce toxic exposure Protect liver: stabilise cell membranes, reduce oxidation, restore glutathione levels Support effective detoxification and liver function Diet plan guidelines to support Detoxification A detoxification or liver cleanse protocol should be considered wherever there is liver dysfunction